Dr. Simon Brust, an uptight professor and rising star in immunology research at Yale, has blind spots when it comes to relationships.
During a fall, he smacks his head on pavement and, concussed, meets Alex Argyle. She's a vivacious, free-spirit who dotes as he heals from his injuries. They discover uncanny compatibilities, a perfect match. But Simon still has feelings for Genevieve, his former, sometimes current, lover.
He's so busy helping his mother and researching how cancer hides from the immune system that he misses warning signs. The red flags escalate into crippling panic attacks. They interfere with his work performance. His friend and colleague, Roberto, recommends he seek therapy. Reluctantly, he does. Under pressure from all sides, he must meet the arduous standards for tenure in order to continue his life's work. But things go awry.