The Spanish-owned banking giant will shut the branches from June amid sweeping changes.
It is also cutting hours across 36 sites and switching 18 to counter-free in moves impacting more than a third of its 444-strong network.
Santander said it will be left with 349 sites, which will include 290 full-service branches and five work cafes.
Ten branches will shut in Scotland, where it has about 40 sites and holds £200billion in customer lending.
The changes will put about 750 jobs at risk - more than four per cent of its 18,000 UK workforce - if the plans get the go-ahead after consultations with unions, the bank said.
The majority of the plan...